Biomedical Engineering Reference
In-Depth Information
droplet pathways can be determined, has been estimated and integrated in
the synthesis flow. The proposed method increases the likelihood that fea-
sible droplet pathways can be found for area-constrained biochip layouts. We
have demonstrated the advantages of this approach using a large-scale pro-
tein assay based on the Bradford reaction. To increase system dependability,
two defect-tolerance schemes, that is, presynthesis and postsynthesis, have
been incorporated into the routing-aware design method. Simulation results
have highlighted the increase in defect tolerance achieved in each case. The
design techniques presented in this chapter relieves the chip user from the
burden of postsynthesis droplet routing, and they facilitate the automated
design of biochips with guaranteed high levels of defect tolerance. In this way,
the biochip user can concentrate on the development of nano- and microscale
bioassays, leaving cumbersome implementation details to the synthesis tools.
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