Biomedical Engineering Reference
In-Depth Information
effective methods to test basic operations such as droplet dispensing, drop-
let transportation, mixing, splitting, and capacitive sensing. In Section 4.6,
these functional test techniques are applied to a fabricated chip. Simulation
results are also presented. Finally, conclusions are drawn in Section 4.7.
Chapter 5 presents DFT for microfluidic biochips. Section 5.1 explains the
testability problem. Section 5.2 presents a testability-aware design method.
In Section 5.3, the proposed test-aware design method is applied to a multi-
plexed bioassay and a PCR assay, and simulation results are presented.
Finally, conclusions are drawn in Section 5.4.
Chapter 6 focuses on application-driven design. In Section 6.1, the automa-
tion tools described in previous chapters are used for the design of a low-cost,
easily manufacturable, high-throughput, and robust chip for protein crystal-
lization. Section 6.2 provides a solution-preparation algorithm that can be
used to derive a preparation plan that lists the intermediate mixing steps
needed to generate the thousands of target solutions with different sample
or reagent concentrations required for protein crystallization. A summary of
the chapter is presented in Section 6.3.
Finally, in Chapter 7, we present conclusions and outline future research
directions in this emerging field of microsystems design automation.
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