Biomedical Engineering Reference
In-Depth Information
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-phase-bus chip
2: array-partitioning-based chip
3: cross-referencing-based chip
4: broadcast-addressing-based chip
Figure 4.45
Functional testability of pin-constrained chips.
multiple test droplets for both online and off-line testing. We have also
identified a number of common defects and defect types. These causes of
defects have been related to fault models and observable errors. The pro-
posed test and diagnosis methods have been evaluated using complexity
analysis and a fabricated chip example. The results obtained demonstrate
significant improvement over prior work on the testing and diagnosis of
digital microfluidic biochips. We have also presented several techniques for
the functional testing of droplet-based microfluidic biochips. These tech-
niques address fundamental biochip operations such as droplet dispensing,
droplet transportation, mixing, splitting, and capacitive sensing. Functional
testing is carried out using parallel droplet pathways, and it leads to
qualified regions where synthesis tools can map microfluidic functional
modules. We have demonstrated functional testing for a fabricated biochip
used for PCR. We have also presented simulation results for a protein assay,
and quantified the small increase in assay completion time that is needed
to achieve 100% coverage of the target defects and malfunctions with func-
tional testing. Finally, we described the application of these functional test
methods to pin-constrained chips.
References
1. Schulte, T. H., R. L. Bardell, and B. H. Weigl, Microfluidic technologies in clinical
diagnostics,
Clinica Chimica Acta
, vol. 321, pp. 1-10, 2002.
2. Srinvasan, V., V. K. Pamula, M. G. Pollack, and R. B. Fair, Clinical diagnostics on
human whole blood, plasma, serum, urine, saliva, sweat, and tears on a digital
