Biomedical Engineering Reference
In-Depth Information
Untested array
Array after structural testing
Array after functional testing
420
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280
0.01
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Malfunction Probability, q
(a)
Untested array
Array after structural testing
Array after functional testing
420
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300
280
0.01
0.02
0.03
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Malfunction Probability, q
(b)
Figure 4.42
Bioassay completion time for synthesized design without test, with structural test, and with
functional test for defect occurrence probability of (a) P[A] = 0.01 and (b) P[A] = 0.05.
assay. As expected, the bioassay time is slightly higher when functional test-
ing is used, and the increase is more for higher values of the malfunction
probability q . This increase is acceptable because functional testing ensures
that the assay will run to completion if the fluidic operations are mapped
only on the qualified region of the array.
Next, we evaluate the functional test scheme on pin-constrained arrays. For
each pin-constrained design method presented in Subsection 4.5.4, we choose
one chip design prototype for discussion, as shown in Figure 4.43. Figure 4.43a
shows a linear chip used the for on-chip dilution. The chip is addressed using
a five-phase bus. Figure 4.43b presents a 10 × 10 array for the multiplexed bio-
assay described in Chapter 2. Figure 4.43c provides an array-partitioning-based
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