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(a)
MnFe
2
O
4
FeFe
2
O
4
CoFe
2
O
4
NiFe
2
O
4
TEM image
(b)
Mass
magnetization
(emu∙g
-1
)
110
101
99
85
Fe
3+
M
2+
O
2-
T
d
site
(c)
Magnetic
spin
structure
5
4
3
2
O
h
site
Magnetic
moment
5 μ
B
4 μ
B
3 μ
B
2 μ
B
(d)
400
300
200
100
0
MnFe
2
O
4
FeFe
2
O
4
CoFe
2
O
4
NiFe
2
O
4
CLIO
(e)
MDA-MB-
231
Cell lines
Relative
HER2/neu
expression
Control
BxPC-3
MCF-7
NIH3T6.7
-
1
3
28
2,300
MnMEIO-
Herceptin
conjugate
treatment
i
ii
iii
iv
v
T
2
-weighted MRI
CLIO-
Herceptin
conjugate
treatment
vi
vii
viii
ix
x
fIgure 2.5
(a) TEM images of 12 nm MnFe
2
O
4
NPs (M = Mn, Fe, co, Ni) and (b) their
mass magnetizations and (c) their schematic spin moments. (d) Relaxivity
r
2
values of 12 nm
MnFe
2
O
4
NPs (M = Mn, Fe, co, Ni) and clIO at 1.5
T
. (e)
T
2
-weighted MR images of cell
lines treated with MnMEIO-Herceptin conjugate and clIO-Herceptin conjugates. (Reprinted
with permission from Ref. [27]. © Macmillan Publishers ltd.)
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