The Application of Plant Viral Nanoparticles in Tissue-Specific Imaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 412

in vivo , with evaluations mainly providing evidence of the feasibility of these plat-
forms on the benchtop or in vitro . preliminary work has begun to evaluate the bio-
distribution and pharmacokinetics of these VNps in vivo . Considering the advantages
and versatility of the VNp platform compared to conventional nanoparticles, it is
crucial that these nanoparticles are evaluated in more detail to accelerate translation
from bench to bedside.
There is a great future for VNps in imaging. We foresee that state-of-the-art mul-
timodal formulations for simultaneous disease detection, imaging, and treatment
will be developed by combining the various applications shown here for targeting,
drug delivery, fluorescence, luminescence, and Mri and peT imaging. There are
endless possibilities!
AcknowledgmenTs
This work was supported by Nih/NiBiB grants r00 eB009105 (to NFS) and p30
eB011317 (to NFS) and training grant T32 eB007509 (to AMW), Mt. Sinai Foundation
(to NFS), and prostate Cancer Canada grant 2011-742 (to JDL).
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