The Application of Plant Viral Nanoparticles in Tissue-Specific Imaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 410

(b) [ 18 F]-MS2 capsids

Heart Heart

Liver

(a)

[ 18 [18F]fluorobenzaldehyde

15 s 60 s 5 min 30 min

Bladder/urine

Bladder/urine

Kidneys

15 s 60 s 5 min 30 min

1 h 2 h 3 h

(d)

FDG FEAU FEAU FDG

BR BR

T T

H T

T

H

% ID/g
5
2
1
0.5
0.2
0.1
0.05
0.02
0.01

(c)

4.0
3.5

BR BR

T T T

T

H

H

3.0

2.5

2.0

1.5

1.0

BL BL BL BL

Non-targeted
AAVP

Scrambled
AAVP

RGD-4C
AAVP

Before GCV After GCV

figure 14.7 peT images of Sprague-Dawley rats injected with [ 18 [18F]fluorobenzaldehyde
(a) and [ 18 F]-MS2 (b). Grayscale transmission scan renderings are shown in the background,
and intensities were scaled to the maximum in each frame. (Figure (a, b) were reproduced with
permission from ref. [109]. © Springer Science and Business Media.) (c) Bioluminescent
images of luciferase expression in nude mice bearing DU145 tumor xenografts ten days after
delivery of AAVp. The targeted rGD formulation showed successful gene delivery, while the
nontargeted and scrambled formulations did not. (d) peT images of [ 18 F]FeAU and [ 18 F]FDG
accumulation in nude mice bearing DU145 tumor xenografts before and after GVC therapy.
BL, bladder; Br, brain; h, heart; T, tumor. (Figure (c, d) were reprinted with permission from
ref. [110]. © elsevier.) ( See insert for color representation of the figure.)

The use of VNps for peT imaging applications is very novel and work is still
ongoing. Aside from MS2, hemagglutinating virus of Japan envelopes (hVJ-e) has
also been employed as carriers of peT tracers. Superparamagnetic ferumoxide parti-
cles and 18 F-fluoride were loaded simultaneously within these envelopes, and it was