The Application of Plant Viral Nanoparticles in Tissue-Specific Imaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 392

14

The ApplicATion of plAnT VirAl
nAnopArTicles in Tissue-specific
imAging *

Amy M. Wen

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA

Choi-Fong Cho

Harvey Cushing Neuro-Oncology Laboratories, Brigham and Women's Hospital, Harvard
Medical School, Boston, MA, USA

John D. Lewis
Translational Prostate Cancer Research Group, Department of Oncology, University of
Alberta, Edmonton, Alberta, Canada

Nicole F. Steinmetz

Departments of Biomedical Engineering, Radiology, Materials Science and Engineering,
and Macromolecular Science and Engineering, Case Western Reserve University, Cleveland,
OH, USA
Department of Macromolecular Science and Engineering, Case Western Reserve University,
Cleveland, OH, USA

14.1 inTroducTion

The application of nanotechnology in medicine has led to advances in early detection,
imaging, and treatment of disease. The ability to exploit nanoparticles to diagnose,
treat, and monitor disease progression without surgery, biopsy, or other invasive meth-
odologies has the potential to increase survival, improve quality of life, and reduce
costs. Advancements in bioconjugation and self-assembly have led to the generation

*Amy M. Wen and Choi-Fong Cho contributed equally.