Pandia: Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans - Nanotechnology for Biomedical Imaging and Diagnostics - page 354

Pre-Tx Tx Day 7 Day 14

Pre-Tx Day 7 Day 14

FiGure 12.12 Patient treatment response from pretreatment to day 14.

Pre-Tx Day 14 2 months

FiGure 12.13 dog 1 complete recovery after the treatment.

TaBle 12.3 list of histopath Posttreatment for seven canines used in the study

Patient Response histopath posttreatment

1 CR Tumor still evident at day 14 but regressed over time

2 Sd No evidence of tumor cell death; uncharged from pretreatment

3 Sd 60% necrosis with hemorrhage, tumor still present

4 Sd Fibrin, hemorrhage, skin necrosis, tumor present but completely

removed

5 Sd Multifocal mild hemorrhage and necrosis but <50%; tumor present

6 Sd No evidence of tumor cell death or necrosis on histopath

7 Sd Not done yet

CR, complete response; Sd, stable disease.

detected in the serum and plasma immediately after administration and were
completely cleared within 72 h in most dogs. The application of the NIR diode
laser resulted in rapid tumor heating. Much of tumor heating appeared to
concentrate in the skin, and the use of an amplitude-modulated laser may induce