Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents - Nanotechnology for Biomedical Imaging and Diagnostics - page 295

(b)

(a)

1.5 2.0 4.0

0 0.3 0.5 1.0 5.5 ml

50 nm

(c)

25

ext.

20

15

abs.

33.4 nm
45 nm

0

10

600 800
Wavelength (nm)

400 1000

sca.

5

0

500 600

Wavelength (nm)

700 800

400

figure 10.6 optical and physical properties of gold nanocages (gnCs). (a) Various types
of gnCs prepared by reacting Au nanocube solution with different volumes of HAuCl 4 solution
(reprinted with permission from ref. [122]. © American Chemical Society.). (b) TEM image
of gnCs with an edge length of 55 nm (reprinted with permission from ref. [76]. © American
Chemical Society.). (c) Calculated optical spectrum of gnCs with an outer edge length of
45.0 nm and wall thickness of 5.8 nm. (reprinted with permission from ref. [124]. © American
Chemical Society.)

6 h

(a)

(b)

Tumor

SLN

5 mm

[Nle 4 , D -Phe 7 ]-α-MSH-GNCs

figure 10.7 In vivo photoacoustic (PA) imaging of gnCs in small animals. (a) In vivo
noninvasive PA images of B16 melanomas in a nude mouse acquired at 6 h post-intravenous
injection of [nle4,d-Phe7]-α-MSH-gnCs (reprinted with permission from ref. [76]. ©
American Chemical Society.). (b) In vivo PA images of sentinel lymph nodes of a rat acquired
after the intradermal injection of gnCs. (reprinted with permission from ref. [119]. © American
Chemical Society.)