Radio-labeled Nanoparticles for Biomedical Imaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 198

(a)

(b)

10 min 30 min 1h 1h 30 min 3h 5h

(c) (d)

10 1.00

8 0.80

6 0.60

4 0.40

15 nm

2 0.20

0 0.00

ICP-MS Radioactivity

( γ count)

figuRe 7.2 (a) Small animal SpeCT/CT of 125 I-cRp-AuNps and (b) cold-form-blocked
125 I-cRgD-AuNps in nude mice bearing U87mg tumors xenografts after injection through tail
vein. The SpeCT/CT studies were performed serially from 0 to 5 h after injection of 11.1 mbq
radiolabeled AuNps. Yellow circles indicates tumor region. (c) Tem images of gold nanopar-
ticles obtained from urine samples. (d) biodistribution comparison of cRpAuNps (inductively
coupled plasma mass spectrometry [ICp-mS]) and iodine-125 (γ count). Data obtained from
tumor 1 h after injection. %ID = injection dose. (With permission from Ref. [87]. © Wiley.)
( See insert for color representation of the figure.)