Nanoparticles as Contrast Agents for Optoacoustic Imaging - Nanotechnology for Biomedical Imaging and Diagnostics - page 127

PreGNR PostGNR 1 h PostGNR 1day PostGNR 2 days PostGNR 8 days

4

3

1

2

5

765

PreGNR PostGNR 1 h PostGNR 1 day PostGNR 2 days PostGNR 8 days

4

5

3

2

1

1064

figure 5.13 Three-dimensional OAT dorsoventral reconstruction from a mouse before
and after intravenous injection of gold nanorod-Peg solution for 765 and 1064 nm laser illu-
mination. The locations of the image areas used for analysis of organ-specific changes on each
view are outlined: (1) left kidney, (2) right kidney, (3) spleen, (4) spine, and (5) whole body.
(Adapted with permission from Ref. [15]. © sPIe-International society for Optical engineers.)

formation of metal nanostructures with hollow interiors can be attained from
various types of metals [143]. The major steps in manufacturing hollow nanoparti-
cles are shown in figure 5.14 with Tem images of silver nanoparticles and
corresponding hollow gold nanostructures obtained by aqueous HAucl 4 solution.
gold nanocages feature single-crystal structure, hollow interiors, ultrathin and
porous walls, and high molar absorptivity [145]. Due to their strong optical absorption,
nanocages can be melted even by a camera flash discharge [146].
Hollow gold nanocages have been explored in a number of biomedical applica-
tions, often in cancer detection and treatment [147]. gold nanocages are particularly
applicable for in vivo OA imaging because of the compact size, bioinertness, and