Hollow Nanocapsules in Biomedical Imaging Applications - Nanotechnology for Biomedical Imaging and Diagnostics - page 101

challenge is to bring the size of LBL capsules to sub-100 nm scale while maintaining
adequate payload capacity. The chemical toolbox available for constructing polymer
micelles and polymersomes is diverse, and natural motifs have been actively incor-
porated into their designs.
Different types of polymeric capsules can be used for a broad range of biomedical
applications, particularly for imaging or combination of imaging with therapeutic
function. The field of hollow NCs is rapidly growing, and recent years saw significant
advances in controlled encapsulation, triggered release, and programmed permeability
of NC shells. Future developments are likely to focus on targeted delivery, expanded
in vivo applications, and construction of practical devices for medical diagnostics.
ackNowledgmeNts
We thank Amy Harkins and Jason Papke for imaging NCs in neurons (Fig. 4.15).
This work was supported by the National Science Foundation (CHE-1316680),
National Institutes of Health (1 R21AR060408-01A1), and Saint Louis university
Presidential Research Fund.
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