Vibrational Spectroscopy and Cancer - Vibrational Spectroscopy for Tissue Analysis - page 69

The results obtained from histopathological analysis were used to confirm
the results of the statistical analysis. The results showed that the only sig-
nificant difference between the peaks of the spectra of normal tissues and
those of lesion borders is a peak at 538 cm −1 . This peak is related to disulfide
bridges in cysteine, and it seems to be the main factor for the FT-Raman
determination of the boundaries between healthy and pathological tissue.

Skin Cancer
A number of researchers have been working on skin cancer employing spec-
troscopic techniques (Table 4.6). The study of S. Sukuta and R. Bruch was on
factor analysis of cancer FTIR fibreoptic evanescent wave (FTIR-FEW) spec-
tra. The purpose of the research was to isolate pure biochemical compounds
and spectra and to classify skin cancer tumours. Apart from fulfilling the
primary goals, it was demonstrated that the combination of the FTIR-FEW

Table 4.6
Articles on Skin Cancer
Research
Group

Research
Method

Investigated
Tissue or Sample

Effectiveness of
the Technique

Reference
Number

Sukuta and
Bruch

FTIR Skin + 84

Cheng et al. Raman Skin + 85

Kaminaka et al. Raman Skin and lung + 86

Sigurdsson et al. Raman Skin + 87

Gniadecka et al. Raman Skin + 88

Panjehpour et al. Fluorescence

spectroscopy

Skin + 89

Wong et al. Pressure-tuning

infrared
spectroscopy

Skin + 90

Lucassen et al. ATR-FTIR Skin + 91

McIntosh et al. FTIR Skin + 92

Barry et al. FTIR and

FT-Raman

Skin + 93

Huang et al. Raman and NI

autofluorescence

Skin + 94

Caspers et al. Raman Skin + 95

Ly et al. FTIR imaging Skin and colon + 96

Lieber et al. Raman Skin + 97

Hammody et al. FTIR Melanoma and

Epidermis

+ 98