Vibrational Spectroscopy and Cancer - Vibrational Spectroscopy for Tissue Analysis - page 58

Cervical and Ovarian Cancers
Murali Krishna et al. published another review article on applications of
optical spectroscopy in cervical cancers [48]. This review includes a brief
background on the anatomy and histology of the uterine cervix and the eti-
ology of cervical cancers, along with a brief discussion of the optical spec-
troscopic approach to cervical cancer diagnosis. Radiation therapy, radiation
resistance, and Raman spectroscopic methodologies in cervical cancer diag-
nosis were also covered in this publication.
Cervical and ovarian tissues have been widely investigated by differ-
ent research groups (Table 4.2). B. R. Wood et al. made an investigation on
Fourier transform infrared (FTIR) spectroscopy as a biodiagnostic tool for
cervical cancer. The spectra of the normal epithelial cells illustrated intense
glycogen bands at 1022 cm −1 and 1150 cm −1 , and a pronounced symmetric
phosphate stretch at 1078 cm −1 . The spectral features suggestive of dysplas-
tic or malignant transformations were mainly pronounced symmetric and
asymmetric phosphate modes and a reduction in the glycogen band inten-
sity. This study demonstrated the potential of the automated FTIR cervical
screening technology in the clinical environment [49].
Chiriboga et al. carried out research on differentiation and maturation
of the epithelial cells in the human cervix, using infrared spectroscopy.

Table 4.2
Articles on Cervical and Ovarian Tissue

Investigated
Tissue or
Sample

Effectiveness of
the Technique

Reference
Number Research Group Research Method

Wood et al. FTIR Cervical tissue + 49

Chiriboga et al. FTIR Cervix + 50

Wood et al. FTIR Cervical tissue + 51

Utzinger et al. Raman Cervical tissue + 52

Sindhuphak et al. FTIR Cervical tissue + 53

Mordechai et al. FTIR Cervical tissue + 54

Chiriboga et al. FTIR Cervical tissue + 55

Wong et al. FTIR Endocervix

and ectocervix

+ 56

Fung et al. FTIR Endometrium + 57

Krishna et al. Raman + Principal

Components
Analysis (PCA)

Human uterine
cervix

+ 58

Maheedhar et al. Raman Ovarian tissue + 59

Mo et al. Raman Cervical tissue + 60

Jess et al. Raman Cervical tissue + 61

El-Tawil et al. FTIR Cervical tissue + 62