Future Potential Clinical Applications of Spectroscopic Techniques in Human Diseases - Vibrational Spectroscopy for Tissue Analysis - page 319

13

1: CH region
2: Amide I
3: C=C (Protein Assignment)
4: CH 2 /CH 3 (Proteins + Phospholips)
5: CH 3 CH 2 wagging (Nucleic acids + Proteins)
6: Amide III
7: Aromatic CO and CN
8: vs PO 2 - (Nucleic acids + Phospholipids)
9: C-O stretching (Carbohydrates)

1100
1000
900
800
700
600
500

11 12

8 9

6

4

7

10

5

2

3

10: vs (C-C) (Proteins)
11: p(CH 2 /CH 2 ) + v(C-C) (Proteins)
12: v(C-C), δ(CCH) (Proteins + Polysaccharides)
13: O-P-O of DNA

400
300
200
100
0

: Sudden decrease in peak intensities

Pink : A2780S-Control
Red : A2789SCis-0.3umCDDP
Blue : A2789SCis-1umCDDP
Green : A2789SCis-3umCDDP

1

3000 2500 2000

Raman Shift (cm -1 )

1500 1000

Figure 6.9
Changes in spectra of treated S samples.

1700
1600
1500
1400
1300
1200
1100

Formation of
new shoulder

1000
900
800
700
600
500
400

Red : A2780R-Control
Blue : A2789RCis-10umCDDP
Green : A2789RCis-20umCDDP
Purple : A2789RCis-30umCDDP

1600 1400 1200

Raman Shift (cm -1 )

1000 800

Figure 6.10
Treated R spectra, fingerprint region.

500
400
300
200
100

Red : A2780R-Control
Blue : A2789RCis-10umCDDP
Green : A2789RCis-20umCDDP
Purple : A2789RCis-30umCDDP

3000
Gradual decrease of the
peak intensities of the R
samples in the CH region

Figure 6.11
Treated R spectra, CH region.