Detecting and Monitoring of Cancer at the Cellular Level - Vibrational Spectroscopy for Tissue Analysis - page 178

1700
1600
1500
1400
1300
1200
1100

Formation of
new shoulder

1000
900
800
700
600
500
400

Red : A2780R-Control
Blue : A2789RCis-10umCDDP
Green : A2789RCis-20umCDDP
Purple : A2789RCis-30umCDDP

1600 1400 1200

Raman Shift (cm -1 )

1000 800

Figure 6.10 (See colour insert.)
Treated R spectra, fingerprint region.

500
400
300
200
100

Red : A2780R-Control
Blue : A2789RCis-10umCDDP
Green : A2789RCis-20umCDDP
Purple : A2789RCis-30umCDDP

3000
Gradual decrease of the
peak intensities of the R
samples in the CH region

Figure 6.11 (See colour insert.)
Treated R spectra, CH region.

similar to other spectral areas, applying stronger medications does not result
in further change in the peak intensities.
The results clearly indicate that Raman spectroscopy can be objectively
applied on the treated cell lines. The technique can open new horizons in
oncologic and cytologic information.
A summary of the findings are given here:

• The sensitive cell lines undergo signiicant changes under the inlu-
ence of chemotherapeutic drugs. This effect is observed in the cell
lines treated with the lowest concentrations of the medication, and
subsequent increases in the strength of the medication do not lead
to dramatic changes.