Biomedical Engineering Reference
In-Depth Information
The HNG spectra appear to differ more in intensity than in shape, which is
clear from Figure 5.46.
Healthy Normal Tissue
The histogram for normal tissue indicates two poorly separated clusters
and there is a spatial basis to the clustering as presented in Figure  5.47.
There appears to be a significant difference in the spectra at about 1000 cm −1 ,
but plotting the second-derivative spectra reveals that this is mostly due
to the sloping baseline rather than any differences among the samples
(Figure 5.48).
These differences could be due to variations in the tissue, but they are
certainly not as dramatic as those observed for some of the earlier samples
of GI, GII, GIII, and HNG. These spectra, being representative of healthy tis-
sue, may be helpful in assigning clusters found earlier as either healthy or
cancerous.
0.3
0.25
3
0.2
0.15
2
0.1
0.05
1
1000
1500
2000
Wavenumber
Figure 5.46
HNG: a plot of some of the original spectra (wavenumber cm −1 ).
× 10 -4
30
1
20
0
10
-1
0
-5
-4
-3
-2
× 10 -4
0
30
10
20
T1
x
Figure 5.47
Normal: clustering histogram for T1 and T2 and the clusters plotted with their ( x , y ) coordinates.
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