Infrared and Raman Spectroscopy and Imaging of Breast Cancer - Vibrational Spectroscopy for Tissue Analysis - page 114

0.9 Black : Grade I

Red : Grade II
Blue : Grade III

0.8

0.7

0.6

0.5

0.4

0.3

0.2

0.1

3000 2500 2000

Raman Shift (cm -1 )

1500 1000 500

Figure 5.2 (See colour insert.)
Raman spectra of different IDC grades.

Black : LNG
Blue : ING
Red : HNG

0.75
0.70
0.65
0.60
0.55
0.50

0.45
0.40
0.35
0.30
0.25
0.20
0.15
0.10

3000 2500 2000 1500 1000 500

Raman Shift (cm -1 )

Figure 5.3 (See colour insert.)
Raman spectra of different DCIS grades.

features that are manifestations of unique biological processes. The direct
detection of these biochemical constituents may provide a new methodology
for noninvasive detection of disease processes, together with information
for classifying, grading, and evaluating the progression of malignant neo-
plasms to provide a potential diagnostic tool. The spectrum of the normal
tissue has well-defined peaks in the region 3500-650 cm −1 . Assignment of the
peaks is presented in Table 5.2.