The Secretory Pathway From History to the State of the Art - Fusion of Biological Membranes and Related Problems - page 10

Table 1
Coat Proteins of Vesicles of the Secretory Pathway

Subunits Size
Protein Complex Mammals Yeast Mammals Features / Interactions

COPII
Sec13 complex hSec13p Sec13p ~34 kDa WD-40 repeats

hSec31p Sec31p ~150 kDa WD -40 repeats

Sec23 complex hSec23p Sec23p ~85 kDa GAP for Sar1p Sec16p

~ 105 kDa

hSec24p Sec24p ~ Bos1p, Bet1p

Sar1 hSar1p Sar1p ~21 kDa Ras - GTPase / Bos1p

COPI
Coatomer α -COP Ret1p ~140 kDa WD - 40 repeats / β′ -COP, ε -COP

β -COP Sec26p ~ 107 kDa δ -COP, ARF1

β′ -COP Sec27p ~ 102kDa WWD-40 repeats / α -COP

γ -COP Sec21p ~ 97 kDa - ζ - COP, ARF1, KKXX,

p24 family

δ -COP Ret2p ~57 kDa β -COP

α - COP

ε -COP Sec28p ~35 kDa a-

ζ -COP Ret3p ~20 kDa γ -COP

ARF 1 ARF 1 yARF ~20 kDa - Ras GTPase / β -COP, γ -COP,

Clathrin-Adaptor 1
AP1 complex γ -Adaptin Ap14p ~100 kDa σ 1-Adaptin

β 1-Adaptin Ap12p ~100 kDa µ1-Adaptin, Clathrin hc, di-Leu-

based motifs

µ1-Adaptin Apm1p ~ 50 kDa β 1-Adaptin, Tyr-based motifs

σ 1-Adaptin Aps1p ~ 19 kDa γ -Adaptin

Clathrin 3 hc* CHC1 ~190 kDa β 1-Adaptin, hsc70, β -arrestin

3Ic ∆ CLC1 ~30-40 kDa

ARF 1 yARF ~20 kDa Ras-GTPase

Clathrin-Adaptor 3
AP3 complex

δ -Adaptin Ap15p ~160 kDa

β 3-Adaptin Ap16p ~120 kDa Clathrin, di-Leu-based motifs

µ3-Adaptin Amp3p ~50 kDa Tyr-based motifs

σ 3-Adaptin Ams3p ~25 kDa

~ 190 kDa Clathrin 3 hc* CHC1 β 3-Adaptin, hsc70, β -arrestin

3Ic ∆ CLC1 ~30-40 kDa

* heavy chain
∆ light chain