Annexins and Membrane Fusion - Fusion of Biological Membranes and Related Problems - page 76

FIGURE 1. Structural organization of an annexin molecule. a) The four C-terminal repeats
(I, 11, III & IV) each consist of five alpha-helices (A-E). Helices A, B, D and E are oriented
(anti-) parallel, whereas helix C lies perpendicular to them. b) Stereoview of an annexin V
molecule, viewed from the convex membrane-binding site, showing the central pore (asterisk)
(modified from Voges et al. (1995). c) Schematic drawing showing the side-view of an annexin
molecule. The Ca 2+ binding sites are located on the convex side of the molecule, whereas the
N-terminus resides on the concave side.