Chemistry Reference
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composite has been prepared using of solution-casting-evaporation method. In this
method, the CNT/CS films were prepared by casting and then drying of CNT/CS
solution on the surface of glassy carbon electrode. This CNT/CS system showed a
new biocomposite platform for development of dehydrogenase-based electrochemi-
cal biosensors due to providing a signal transducing of CNT. The great results of this
composite in biomedical application led to many studies in this context.
The effect of CNT/CS matrix on direct electron transfer of glucose oxidase (GOD)
and glucose biosensor was examined by Liu and Dong
et al. [121]. They exhibited
high sensitivity and better stability of CNT/CS composites compared with pure CS
fi lms. Furthermore, Tkac et al. [122] used the SWNT/CS fi lms for preparation a new
galactose biosensor with highly reliable detection of galactose. Tsai et al. [123] immo-
bilized lactate dehydrogenase within MWNT/CS nanocomposite for producing lactate
biosensors. This proposed biosensor provided a fast response time and high sensitivity.
Also, Zhou and chen et al. [124] showed the immobilization of GOD molecules into
CS wrapped SWNT fi lm is an effi cient method for the development of a new class of
very sensitive, stable, and reproducible electrochemical biosensors.
Several experiments were performed on DNA biosensor based on CS fi lm doped
with CNTs by Yao et al. [125]. They found that CNT/CS fi lm can be used as a stable
and sensitive platform for DNA detection. The results demonstrated to improve sen-
sor performance by adding CNT to CS fi lm. Moreover, the analytical performance of
glassy carbon electrodes modifi ed with a dispersion of MWNT/CS for quantifi cation
of DNA was reported by Bollo et al. [126]. The new platform immobilizes the DNA
and opens the doors to new strategies for development of biosensors. In other experi-
ments, Zeng et al. [127] reported high sensitivity of glassy carbon electrode modifi ed
by MWNT-CS for cathodic stripping voltammetric measurement of bromide (Br
-
).
Qian et al. [128] prepared amperometric hydrogen peroxide biosensor based on com-
posite fi lm of MWNT/CS. The results showed excellent electrocatalytical activity of
the biosensor for H
2
O
2
with good repeatability and stability.
Liu and Dong et al. [129] reported effect of CNT/CS matrix on amperometric
lactase biosensor. Results showed some major advantages of this biosensor involving
detecting different substrates, possessing high affi nity and sensitivity, durable long-
term stability, and facile preparation procedure.
Gordon Wallace and his coworkers [130] with particular attention paid to pre-
paring of SWNT/CS fi lm by solution-cast method and then characterized their drug
delivery properties. They found that the SWNT/CS fi lm decrease the release rate
of dexamethasone. Growth of apatite on CS-MWNT composite membranes at low
MWNT concentrations was reported by Yang et al. [131]. Apatite was formed on the
composites with low concentrations. Immune-sensors can detect various substances
from bacteria to environmental pollutants. CNT/CS nano-biocomposite for immune-
sensor fabricated by kaushik et al. [132]. Electron transport in this nano-biocomposite
enhanced and improved the detection of ochratoxin-A, due to high electrochemical
properties of SWNT. Also, CNT/CS nanocomposite used for detection of human cho-
rionic gonadotrophin antibody was performed by Yang et al. [133] and displayed high
sensitivity including good reproducibility.
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