Biomedical Engineering Reference
In-Depth Information
N
N
N
N
3, Pentylenetetrazole
O
N
O
H
H
O
O
O
O
4, Bicuculline
Ph
B
-
Ph
CN
Ph
5, Cyanotriphenylborate
4.2 Agents Acting with Chloride Channels in Muscle Cells
In a review, Bretag [
167
] discussed four groups of compounds that act as chloride
channel blockers in striated muscle cells: (1) polycyclics, (2) benzoates, (3)
phenoxyacetates, and (4) sulfonates and sulfonamides. The representative
compounds of these groups can be cited as anthracene-9-carboxylate (6, 9-Ac),
furosemide (7), ethacrynic acid (8), and stilbene disulfonate (9), respectively.
Further, two sulfonic acid stilbene derivatives, 4-acetamide-4
0
-isothiocya-
nostilbene-2,2
0
-disulfonate (SITS) and 4,4
0
-diisothiocyanostilbene-2,2
0
-disulfonate
(DIDS), were also assumed to interfere with chloride channels in smooth muscle
cells in analogy to their effects in
Torpedo
electric organ chloride channel [
168
].
O
-
6, Anthracene-9-carboxylate
