Biomedical Engineering Reference
In-Depth Information
Table 1 Current status of N-type Ca
2+
channel blockers
Drug/chemical structure
Use
Stage
Side effects
Ziconotide/Prialt
TM
H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-
Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-
Arg-Ser-Gly-Lys-Cys-NH
2
Neuropathic pain
and cancer pain
Hypotension, sedation, confusion, ataxia, and
memory impairment
Clinical
Morphine
HO
O
Chronic, neuropathic and
inflammatory pain
Constipation, narcotic and addictive effects,
as well as the development of tolerance
H
N
Clinical
HO
Gabapentin (Neurontin)
CH
2
NH
2
Hyperkinesia, dizziness, somnolence, and
peripheral edema
CH
2
CO
2
H
Neuropathic pain
Clinical
(continued)
