Biomedical Engineering Reference
In-Depth Information
21. Gong Q, Keeney DR, Robinson JC et al (2004) Defective assembly and trafficking of mutant
HERG channels with C-terminal truncations in long QT syndrome. J Mol Cell Cardiol
37:1225-1233
22. Obers S, Staudacher I, Ficker E et al (2010) Multiple mechanisms of hERG liability: K+
current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.
Naunyn Schmiedebergs Arch Pharmacol 381:385-400
23. Staudacher I, Schweizer PA, Katus HA et al (2010) hERG: protein trafficking and potential
for therapy and drug side effects. Curr Opin Drug Discov Devel 13:23-30
24. Schmitt N, Calloe K, Nielsen NH et al (2007) The novel C-terminal KCNQ1 mutation
M520R alters protein trafficking. Biochem Biophys Res Commun 358:304-310
25. Chen J, Chen K, Sroubek J et al (2010) Post-transcriptional control of human ether-a-go-go-
related gene potassium channel protein by alpha-adrenergic receptor stimulation. Mol
Pharmacol 78:186-197
26. Mosley CA, Myers SJ, Murray EE et al (2009) Synthesis, structural activity-relationships,
and biological evaluation of novel amide-based allosteric binding site antagonists in
NR1A/NR2B N-methyl-D-aspartate receptors. Bioorg Med Chem 17:6463-6480
27. Wang L, Dennis AT, Trieu P et al (2009) Intracellular potassium stabilizes human ether-a-
go-go-related gene channels for export from endoplasmic reticulum. Mol Pharmacol
75:927-937
28. Anumonwo JM, Horta J, Delmar M et al (1999) Proton and zinc effects on HERG currents.
Biophys J 77:282-298
29. Chen J, Sroubek J, Krishnan Y et al (2009) PKA phosphorylation of HERG protein regulates
the rate of channel synthesis. Am J Physiol Heart Circ Physiol 296:H1244-H1254
30. Vandenberg JI, Varghese A, Lu Y et al (2006) Temperature dependence of human ether-a-
go-go-related gene K+ currents. Am J Physiol Cell Physiol 291:C165-C175
31. Milnes JT, Witchel HJ, Leaney JL et al (2010) Investigating dynamic protocol-dependence
of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide. J
Pharmacol Toxicol Methods 61:178-191
32. Afrasiabi E, Hietamaki M, Viitanen T et al (2010) Expression and significance of HERG
(KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell prolifera-
tion and migration. Cell Signal 22:57-64
33. Gustina AS, Trudeau MC (2009) A recombinant N-terminal domain fully restores deactiva-
tion gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proc
Natl Acad Sci USA 106:13082-13087
34. Hancox JC, James AF (2008) Refining insights into high-affinity drug binding to the human
ether-a-go-go-related gene potassium channel. Mol Pharmacol 73:1592-1595
35. Delisle BP, Underkofler HA, Moungey BM et al (2009) Small GTPase determinants for the
Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+
channels. J Biol Chem 284:2844-2853
36. Hancox JC, Witchel HJ, Varghese A (1998) Alteration of HERG current profile during the
cardiac ventricular action potential, following a pore mutation. Biochem Biophys Res
Commun 253:719-724
37. Ganapathi SB, Kester M, Elmslie KS (2009) State-dependent block of HERG potassium
channels by R-roscovitine: implications for cancer therapy. Am J Physiol Cell Physiol 296:
C701-C710
38. Jiang M, Zhang M, Maslennikov IV et al (2005) Dynamic conformational changes of
extracellular S5-P linkers in the hERG channel. J Physiol 569:75-89
39. Babij P, Askew GR, Nieuwenhuijsen B et al (1998) Inhibition of cardiac delayed rectifier K+
current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic
mice. Circ Res 83:668-678
40. Perrin MJ, Kuchel PW, Campbell TJ et al (2008) Drug binding to the inactivated state is
necessary but not sufficient for high-affinity binding to human ether-a-go-go-related gene
channels. Mol Pharmacol 74:1443-1452
