Biomedical Engineering Reference
In-Depth Information
Table 1 List of
hERG
K
+
channels (K
v
11.1) activators
Name
Structures
PD307243
N
Cl
N
H
Cl
O
OH
NS3623
N
N
N
NH
N
H
F
3
C
O
Br
NS1643
OH
OH
H
N
H
O
CF
3
CF
3
A935142
O
F
3
C
OH
HN
N
RPR26024
O
F
N
F
N
O
HO
O
F
and ibutilide prolong cardiac repolarization mainly by reducing outward
repolarizing potassium currents, notably IK
r
at the level of single myocytes [
47
].
The exact incidence of drug-induced
Tdp
in general population is unknown.
Most of our understandings of incidence, risk factors and drug interaction of
