Biomedical Engineering Reference
In-Depth Information
K
+
channel
Ca
2
+ activated
K
+
channel (K
Ca
)
6TM/1P
Two P K
+
channel
(K
2P
)
4TM/2P
Voltage gated
K
+
channel (K
v
)
6TM/1P
Inwa rdly rectifying
K
+
channel (K
ir
)
2TM/1P
Subfamily
K
ir
1.1
K
2P
1.1
K
Ca
1.1
K
v
1.1- 1.8
K
ir
2.1-2.4
K
2P
2.1
K
Ca
2.1-2.3
K
v
2.1- 2.2
K
ir
3.1-3.4
K
2P
3.1
K
Ca
3.1
K
v
3.1- 3.4
K
ir
4.1-4.2
K
2P
4.1
K
Ca
4.1- 4.2
K
v
4.1- 4.3
K
ir
5.1
K
2P
5.1
K
Ca
5.1
K
v
5.1
K
ir
6.1-6.2
K
2P
6.1
K
v
6.1- 6.4
K
ir
7.1
K
2P
7.1
K
v
7.1- 7.5
K
2P
9.1
K
v
8.1- 8.2
K
2P
10.1
K
v
9.1- 9.3
K
2P
12.1
K
v
10.1- 10.2
K
2P
13.1
K
v
11.1- 11.3
K
2P
15.1
K
v
12.1- 12.3
Changes in
K
v
11.1
alters
hERG
channel activity by
varying the repolarization
of action potential
Abnormal
repolarization
Prolonged action
potential duration
hERG
blockade
QT prolongation
Arrhythmia /
Tdp
Sudden Death
Flowchart Classification of the K
+
channels on the basis of IUPHAR and role of
hERG
channel
causing QT prolongation and sometimes
Tdp
. A standardized nomenclature for K
+
channels has
been proposed by NC-IUPHAR subcommittees on K
+
channels. They have been grouped into
different families and subfamilies based on their structure and function. The relevant group/family
is given for each subfamily
