Biomedical Engineering Reference
In-Depth Information
O
N
O
N
O
HN
OH
N
NH
2
O
N
N
quinidine
disopyramide
encainide
O
O
O
N
N
O
N
O
N
H
O
S
OH
moricizine
propafenone
Fig. 6 Sodium channel blockers
N
N
OH
O
O
N
O
N
O
N
O
N
S
O
KC12291
ranolazine
O
S
S
NH
O
F15845
O
OH
OH
N
O
N
N
O
O
O
NC
H
O
O
AZD7009
v
ernakalant (RSD 1235)
Fig. 7 Sodium channel blockers
dependent calcium channels, reducing calcium uptake via the sodium/calcium
exchanger [
184
-
187
]. But ranolazine is only weakly potent against the persistent
sodium current and it is poorly selective versus several potassium channels and, for
these reasons, it is possible to suppose a combination of effects for this drug [
188
].
