Biomedical Engineering Reference
In-Depth Information
(a)
CI
N
Si
OH
N
OEt
OEt
N
EtO
N
MCM-41
Toluene
Re
ux
MBI modi
ed
MCM-41 MSNP
O
N
DMF/TEA
353K
Si
O
HN
Si
O
OEt
OEt
MBI
O
HO
O
OH
7
EtO
β-Cyclodextrin
Cargo
β-CD
Acid
100
(c)
(b)
Cap release
(Pyrene-β-CD)
90
80
70
60
50
40
30
20
10
0
Hoechst
Acid
(pH = 5)
Dox
0 0
100 150
Time (min)
200
250
300
40
H
2
O
(d)
pH 5.0
30
??
??
??
20
pH 6.0
10
Acid
pH 7.0
0
0
100
200
300
400
500
600
Time (min)
FIGURE 3.13
(
See color insert.
) (a) A graphical representation of the pH-responsive MSNP nanovalve. (b)
TEM image of capped MSNP. (c) Fluorescence intensity plots for the release of Hoechst dye,
doxorubicin, and the pyrene-labeled cyclodextrin cap released from MSNP. (d) Release profiles
of doxorubicin from ammonium-modified (7.5%, w/w) nanoparticles showing the faster and
larger response compared to the unmodified MSNP (c). (Reprinted from Meng H., Xue M., Xia
T., et al.,
J. Am. Chem. Soc.
132: 12690-12697, Copyright 2010, American Chemical Society.)
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