Functional Mesoporous Silica Nanoparticles with a Core-Shell Structure for Controllable Drug Delivery - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 65

Ethanol

+ N 2 H

(1)

Ethanol
NH 3 H 2 O
+
TEOS

(2)

Ethanol
NH 3 H 2 O
CTAB
TEOS

(3)

(a)

: FITC or RBITC or R101-SE N 2 H : APTS

(b) (c)

100 nm 100 nm

(d)

(e)

20 nm

FIGURE 3.9
(a) Synthetic route for multifluorescent core-shell MNSs. TEM images of (b) dye-doped silica
cores and (c-d) multifluorescent core-shell MNSs. (e) Confocal fluorescence image of a mix-
ture of eight types of MNSs-IBU under 488 nm argon-ion laser excitation. (Reprinted with
permission from Lei J., Wang L., Zhang J., ACS Nano 5: 3447-3455, Copyright 2011, American
Chemical Society.)

and TEOS to produce dye-doped silica cores; (3) fabricating a mesoporous
layer on the dye-doped silica cores to form core-shell nanoparticles by adopt-
ing the modified Stöber method. The fluorescent signal of a single multicolor
core-shell nanoparticle is about 700 times brighter than its constituent fluo-
rophores. Also, these core-shell nanoparticles showed good drug storage,
sustained release capacity, and biocompatibility (Lei et al. 2011). In addition,
the researchers developed the co-condensation method with the help of the
dehydration reaction between 3-aminopropyltriethoxysilane and dye mol-
ecules to prepare dye-doped mesoporous silica nanoparticles, which also