Biomedical Engineering Reference
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(a)
Coating mesoporous
silica
(b)
C sphere adsorbed Fe
source
Calcined at 550°C
5%H
2
/95%Ar at 350°C
50 nm
(c)
(d)
50 nm
50 nm
180
160
140
120
100
160
140
120
100
80
60
40
20
0
20 µg/ml
60 µg/ml
100 µg/ml
150 µg/ml
200 µg/ml
(e)
24 h
24 h
(f )
0.01 µM
0.1 µM
1 µM
5 µM
80
60
40
20
0
Fe
3
O
4
@SiO
2
-2
DOX
DOX-Fe
3
O
4
@SiO
2
Fe
3
O
4
@SiO
2
Fe
3
O
4
@SiO
2
-1
Fe
3
O
4
@SiO
2
-3
FIGURE 3.7
(a) Schematic procedure for the preparation of rattle-type Fe
3
O
4
@SiO
2
hollow mesoporous
nanoparticles. (b-d)
TEM images of
Fe
3
O
4
@SiO
2
hollow mesoporous nanoparticles with dif-
ferent particle size. (e) Effect of
Fe
3
O
4
@SiO
2
hollow mesoporous nanoparticles with different
particle sizes on the viability of HeLa cells, as measured by MTT assay. (f) Cell viabilities of
free DOX, DOX-loaded
Fe
3
O
4
@SiO
2
, and
Fe
3
O
4
@SiO
2
hollow mesoporous nanoparticles at dif-
ferent concentrations.
(Reprinted with permission from Zhu Y., Ikoma T., Hanagata N., et al.,
Small
6: 471-478, Copyright 2010, Wiley Publishing Company.)
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