Biomedical Engineering Reference
In-Depth Information
3
Functional Mesoporous Silica
Nanoparticles with a Core-Shell Structure
for Controll
able Drug Delivery
Yufang Zhu
CONTENTS
3.1 Introduction .................................................................................................. 47
3.1.1 Amorphous Silica Nanoparticles................................................... 47
3.1.2 Mesoporous Silica Nanoparticles .................................................. 48
3.2 Functional Hollow Mesoporous Silica Nanoparticles for
Controllable Drug Delivery ........................................................................ 49
3.2.1 Preparation of Hollow Mesoporous Silica Nanoparticles ......... 50
3.2.2 Functional Hollow Mesoporous Silica Nanoparticles for
Drug Delivery ................................................................................... 53
3.3 Functional Mesoporous Silica Nanoparticles with a Core-Shell
Structure for Controllable Drug Delivery ................................................ 55
3.3.1 Magnetic Mesoporous Silica Nanoparticles for
Controllable Drug Delivery ............................................................ 55
3.3.2 Luminescent Mesoporous Silica Nanoparticles for
Controllable Drug Delivery ............................................................ 64
3.3.3 Multifunctional Magnetic-Luminescent Mesoporous Silica
Nanoparticles for Controllable Drug Delivery ............................ 67
3.3.4 Other Multifunctional Mesoporous Silica Nanoparticles
for Controllable Drug Delivery ...................................................... 70
3.4 Conclusion and Outlook ............................................................................. 73
Acknowledgments ................................................................................................ 75
References ............................................................................................................... 75
3.1 Introduction
3.1.1 Amorphous Silica Nanoparticles
Silica (SiO
2
) is the most abundant component of the earth's crust except car-
bon, and it can be divided into crystalline and amorphous forms. Crystalline
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