Silicate-Based Bioactive Ceramics for Bone Regeneration Application - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 36

FIGURE 2.5
Osteoblast attachment on akermanite silicate bioceramics.
FIGURE 2.6
Osteoblast growing on porous akermanite silicate ceramic scaffolds for a bone tissue
engineering application. Left: Optical micrograph. Right: SEM micrograph.
including dental pulp cells, bone marrow stromal cells, adipose-derived stem
cells, and periodontal ligament cells, suggesting that silicate ceramics pos-
sess excellent osteostimulation properties in vitro . Akermanite showed the
most distinct osteostimulation properties, which they can stimulate the pro-
liferation for five kinds of cells and osteogenic differentiation for four stem
cells (Sun et al. 2006; Wu, Chang, Ni, et al. 2006; Wu and Chang 2007; Gu et al.
2011; Xia et al. 2011). We found that the Ca, Si, and Mg ions from akermanite
dissolution at certain ranges of concentration significantly stimulated osteo-
blast and L929 cell proliferation (Wu, Chang, Ni, et al. 2006). Further study