Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 17

FIGURE 1.8
BMSCs morphology on MBG scaffolds after culturing for 7 days.
Our recent study revealed that the incorporation of Co 2+ ions into MBG
scaffolds significantly enhanced VEGF protein secretion, hypoxia-induc-
ible factor (HIF)-1α expression, and VEGF gene expression of BMSCs.
The incorporation of Co into MBG scaffolds is an efficient way to pre-
pare hypoxia-mimicking tissue engineering scaffolds with significantly
improved hypoxia function (Wu, Zhou, et al. 2012). The incorporation of
Sr into MBG scaffolds has significantly stimulated the proliferation, ALP
activity, and osteogenesis- and cementogenesis-related gene expression
of periodontal ligament cells. The results suggested that bioactive ions
released from MBG play an important role in enhancing cell response and
their biological functions.
1.4.3 In Vivo Osteogenesis of MBG
To investigate the in vivo osteogenesis of MBG, MBG particles were
implanted into the defects of rat femur. After 8 weeks of implantation, MBG
particles induced a great amount of new bone ingrowths in the defects (see
Figure 1.9). Furthermore, MBG particles were incorporated into silk scaffolds
and investigated the in vivo osteogenesis. The study showed that MBG/silk
scaffolds induced a higher rate of type I collagen synthesis and new bone
formation after implanted in rat calvarial defects compared to conventional
NBG/silk scaffolds. The results confirm that MBG has significant capacity
to improve the in vivo bioactivity of silk scaffolds (Wu, Zhang, et al. 2011).
The preliminary results indicate that MBG has excellent in vivo osteogenesis
for potential bone repair application.