Biomedical Engineering Reference
In-Depth Information
160
Blank control
Scaolds
Scaolds+Ampicillin
140
120
100
80
60
40
20
0
1
3
Time (day)
7
FIGURE 1.6
Sustained release of ampicillin from MBG scaffolds for their significant antibacteria effect.
* Significant difference for the group of scaffolds loaded with ampicillin compared to blank
control and scaffolds groups not loaded with ampicillin (P < 0.05).
Dexamethasone (DEX) was also loaded into MBG scaffolds, and it was
found that the sustained release of DEX from MBG scaffolds significantly
enhanced alkaline phosphatase (ALP) activity and gene expressions (ALP,
BSP, and Col I) of osteoblasts. These results suggest that DEX-loaded MBG
scaffolds show great potential as a release system to enhance osteogenesis
and may be used for bone tissue engineering application (Wu, Miron, et al.
2011; Wu and Chang 2012).
The effect of VEGF delivery from MBG scaffolds on the viability of endo-
thelial cells was further investigated and it was found that the mesopore
structures in MBG scaffolds play an important role in maintaining the
bioactivity of VEGF, further improving the viability of endothelial cells,
indicating that MBG scaffolds are an excellent carrier of VEGF for stimu-
lating angiogenesis.
Dai et al. (2011) incorporated recombinant human bone morphogenetic
protein-2 (rhBMP-2) into MBG scaffolds and showed that the delivery of
rhBMP-2 significantly promoted the
in vitro
osteogenic differentiation of bone
marrow stromal cells and induced the ectopic bone formation in the thigh
muscle pouches of mice. They further found that the delivery of rhBMP-2
resulted in more bone regeneration as compared to MBG scaffolds without
rhBMP-2 (Dai et al. 2011). These studies suggest that MBG materials are a
very useful carrier for drug and growth delivery with improved functions
(Wu and Chang 2012).
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