Bioactive Inorganic and Organic Composite Materials for Bone Regeneration and Gene Delivery - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 214

(a) (b)

0.0 m
MFe mM

0.032 0.016 0.008 0.004 0.002 0.001

Tumor

50 nm

Pre-injection 0.5 h

(c)

100

(d)

pH 5.5 PBS
pH 7.4 PBS

80

60.0*

60

H*

55

40

50

20

PBS

45

0

0 5 10 15 20

40

Time(h)

100

35

(e)

80

30

P<0.05

60

25

40

20.0

20

0

39°C 42°C

Te mperature

45°C

Au NRs-MMSNEs-NIR
Au NRs-MMSNEs-DOX
Au NRs-MMSNEs-DOX-NIR
Additive therapeutic ecacy

FIGURE 3.12
(a) Schematic microscopic structure and TEM image of Au NRs-MMSNEs. (b) T 2 phantom
images of Au NRs-MMSNEs at different Fe concentrations and in vivo MRI of a mouse before
and after intratumor injection of Au NRs-MMSNEs. (c) Infrared thermal imaging under
the photothermal heating by 808-nm laser irradiation for different time periods in Au NRs-
MMSNEs-injected tumor under (up) 1 Wcm -2 and (middle) 2 Wcm -2 irradiations, and (down)
PBS solution-injected tumor under 2 Wcm -2 irradiation. (d) In vitro release profiles of Au
NRs-MMSNEs-DOX using dialysis membrane against PBS solution at pH 7.4 and 5.5. (e) A
comparison of inhibition rates for MCF-7 cells treated by Au NRs-MMSNEs-NIR (purple), Au
NRs-MMSNEs-DOX (red), and Au NRs-MMSNEs-DOX-NIR (green). For photothermal treat-
ment, the media were under 808-nm laser irradiation for 5 min at different power intensities,
corresponding to the maximum temperature increases to 39, 42, and 45°C. (Reprinted from Ma
M., Chen H., Chen Y., et al., Biomaterials 33: 989-998, 2012, with permission from Elsevier Ltd.)