Biomedical Engineering Reference
In-Depth Information
(a)
(b)
FIGURE 7.7
SEM morphology for CaSiO 3 powders (a) before and (b) after calcining at 800°C.
better in vitro BMSC viability and bone-formation ability in vivo compared
to amorphous-CS/PLGA microspheres. The study indicated that controlling
the phase structure of CS is a promising method to modulate the bioactiv-
ity of polymer microsphere systems for potential bone tissue regeneration
(Figure 7.7 and Figure 7.8) (Wu, Zhang, Fan, et al. 2011).
Microspheres have received significant attention as an injectable material
for bone tissue regeneration. Compared with the traditional block scaffolds,
the main advantage of this approach is that minute microspheres can be
combined with a drug vehicle and be administered by injection, opening
up the possibility of filling defects of various shapes and sizes through
minimally invasive surgery (Wu, Zhang, Fan, et al. 2011). Nair et al. (2009)
reported platelet-rich plasma (PRP) or fibrin glue (FG) in combination with
 
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