Biomedical Engineering Reference
In-Depth Information
7
Bioactive Inorganic and Organic
Composite Materials for Bone
Regeneratio
n and Gene Delivery
Yufeng Zhang and Chengtie Wu
CONTENTS
7.1 Introduction ................................................................................................ 178
7.2 Bioactive Inorganic-Organic Composite Materials for Bone
Regeneration ............................................................................................... 181
7.2.1 Composites of Calcium Phosphate Bioceramics and
Polymers .......................................................................................... 182
7.2.1.1 Hydroxyapatite (HAp) .................................................... 182
7.2.1.2 Tricalcium Phosphate (TCP) .......................................... 185
7.2.1.3 Biphasic Calcium Phosphate (BCP) .............................. 188
7.2.2 Composites of Bioactive Glass (BG) or Mesoporous
Bioactive Glass (MBG) and Polymers.......................................... 190
7.2.2.1 Particles ............................................................................ 190
7.2.2.2 Microspheres ................................................................... 192
7.2.2.3 Scaffolds ........................................................................... 192
7.2.3 Composites of Silicate Bioceramics and Polymers .................... 195
7.2.3.1 Particles ............................................................................ 195
7.2.3.2 Microspheres ................................................................... 195
7.2.3.3 Scaffolds ........................................................................... 198
7.3 Gene Delivery ............................................................................................. 198
7.3.1 Calcium Phosphate (CaP)-Based Hybrid Materials for
Gene Delivery ................................................................................. 198
7.3.2 Hybrid Materials Integrated with Gold Nanoparticles
(GNPs) for Gene Delivery ............................................................. 200
7.3.3 Silicate-Based Hybrid Material for Gene Delivery ................... 201
7.3.4 Quantum Dots-Based Hybrid Materials for Gene
Delivery ........................................................................................... 203
7.3.5 Iron-Based Hybrid Materials for Gene Delivery ....................... 203
7.4 Conclusion .................................................................................................. 204
References ............................................................................................................. 205
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