Mesoporous Bioactive Glasses for Drug Delivery and Bone Tissue Regeneration - Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery - page 1

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Mesoporous Bioactive Glasses for Drug
Delivery an d Bone Tissue Regeneration
Chengtie Wu, Jiang Chang, and Yin Xiao
CONTENTS
1.1 Introduction .................................................................................................... 1
1.1.1 Conventional Bioactive Glasses ....................................................... 1
1.1.2 Mesoporous SiO 2 and Mesoporous Bioactive Glass (MBG)
Materials .............................................................................................. 3
1.2 Preparation, Compositions, and Main Forms of MBG ............................. 4
1.2.1 Preparation Methods and Compositions of MBG ......................... 4
1.2.2 Different Forms of MBG: Particles, Fibers, Scaffolds, and
Composites .......................................................................................... 5
1.3 Drug and Growth Factor Delivery of MBG ............................................. 11
1.3.1 Controllable Delivery of Drug and Growth Factor in MBG ...... 11
1.3.2 Drug and Growth Factor Delivery in MBG for
Antibacteria and Tissue-Stimulation Application ...................... 13
1.4 Bone Tissue Engineering of MBG ............................................................. 15
1.4.1 Excellent Apatite-Mineralization Ability of MBG ...................... 15
1.4.2 In Vitro Cell Response to MBG ....................................................... 16
1.4.3 In Vivo Osteogenesis of MBG ......................................................... 17
1.5 Conclusion .................................................................................................... 18
Acknowledgments ................................................................................................ 19
References ............................................................................................................... 19
1.1 Introduction
1.1.1 Conventional Bioactive Glasses
Bioactive glasses have played an increasingly important role in bone tissue
regeneration application by virtue of their generally excellent osteoconduc-
tivity, osteostimulation, and degradation rate (Chen et al. 2006; Jones et al.
2006, 2007; Hench and Thompson 2010; Misra et al. 2010; Wu, Hill, et al. 2011).
The melt-derived bioactive glass, called 45S5 ® bioglass, was pioneered by
Hench (1991, 1998) and was first developed using traditional melt methods