Biomedical Engineering Reference
In-Depth Information
3 Conclusions
Choosing a suitable online analytical technique and data processing method for
bioprocess applications is essential if reliable monitoring and control are to be
achieved. Each of the process analysers described here has the potential to be used
for online measurement, but it is only through proper understanding of their
specific advantages and limitations that they can be applied to monitor the
appropriate process variables. The relationship between the measureable param-
eters and critical process parameters needs to be recognised in order to develop
calibrations for the critical process parameters of interest, and knowledge of the
likely signal interferences will allow the employment of data treatments which can
minimise or even eliminate their effects. Advanced data processing methods such
as data reconciliation and artificial neural networks can also enhance the accuracy
of the measured variables by using inputs from a number of online sensors. The
combination of suitable analytical techniques and data processing methods should
provide an increase in bioprocess knowledge, which will in turn allow the process
to be tightly controlled and operate within a previously established design space.
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