Biomedical Engineering Reference
In-Depth Information
Fig. 24 Bubble chart showing the relationship between cycle number and % step yield of a
chromatography step (X- and Y-axes) compared with HCD concentration (marker size) at BDS
step
Fig. 25 Real-time multivariate monitoring of a seed bioreactor (detection, diagnosis and
inspection steps). Published with copyright permission from Advanstar Communications from
Konold et al. [ 11 ]
(increase in marker size). On the basis of this analysis, a process change was
initiated to repack the column every 30 cycles, replacing the current practice of
packing after every 40 cycles.
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