Biomedical Engineering Reference
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Fig. 5 Functional enviromics of a P. pastoris X33 strain expressing a single-chain antibody
fragment (scFv): a metabolic network, b subset of elementary modes with highest correlation
with the environmental variables. Elementary mode 63 (marked in pink in the network and in the
table) refers to the scFv biosynthesis. c Predicted versus measured fluxes by the method of Eq.
(
11
)
Of the six identified elementary modes, three make by far the largest contri-
bution. Elementary modes 68 and 69 describe the biomass growth, and elementary
mode 63 describes the product synthesis (marked in pink in the network of Fig.
5
).
We have built a macroscopic model with these three elementary modes.
!
dt
¼
X
i
dX
a
X
e
i
;
X
k
i
X
DX
ð
19
Þ
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