Applying Mechanistic Models in Bioprocess Development - Measurement, Monitoring, Modelling, and Control of Bioprocesses - page 147

Fig. 2 Parameter importance indices (d) for the four model variables: glucose, ethanol, dissolved
oxygen and biomass

s

1
n

X

n

s ij

d j ¼ ð 10 Þ

i ¼ 1

The results of the parameter significance ranking indicate that the yield coef-
ficient Y X Oxid is the parameter that most affects all four model outputs. Variations in
the maximum uptake rates will also have a significant effect on the model outputs.
As may be expected, the glucose maximum uptake rate is most significant with
regard to the model prediction for glucose, whereas the maximum uptake rate of
ethanol is most important for the prediction of ethanol and dissolved oxygen.