Bioactive Glass-Based Coatings and Modified Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine - Biological and Biomedical Coatings: Processing and Characterization - page 403

TABLE 9.15
Examples of In Vivo Evaluation of Bioactive Glasses and Glass-Ceramics

Outcome

Inlammation/
Encapsulation

Bone
Formation

Bone
Bridging

Implant
Resorption Material AnimalModel Vascularization Remarks References

BG-P Monkey jaw + + + First observation of

osteoproduction

[36]

BG-P Rabbit femoral

condyl

+ + + + Enhanced bone

formation and
mineralization due
to BG

[13]

Note: BG, bioactive glass, bioglass particles (90-710 μm); P, phosphate.

TABLE 9.16
Examples of In Vivo Evaluation of Bioactive Glasses and Glass-Ceramics

Outcome

Composite
Material

Inlammation/
Encapsulation

Bone
Formation

Bone
Bridging

Implant
Resorption AnimalModel Vascularization Remarks References

BG + PLGA Mouse—

subcutaneous

+ + Peripheral granulation

tissue

[14]

BG + PGA Rat—

subcutaneous

+

BG + PDLLA Rabbit—

subcutaneous,
femur

− + + Rods implanted

Nude mice—
subcutaneous +
BMSC

+ + Collagen I synthesis

BG + PDLLA Sheep—tibia +/− → + + + + Bone inside

pores—osteolysis

Note: BG, bioactive glass; P, phosphate; PLGA, poly-(d/l-lactic-co-glycolic) acid, PGA, polyglycolic acid; PDLLA, poly-(d/l-lactic) acid; BMSC, bone marrow

stromal cells.