Bioactive Glass-Based Coatings and Modified Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine - Biological and Biomedical Coatings: Processing and Characterization - page 400

TABLE 9.12
Cellular Evaluation of Bioactive Glasses

Outcome

Viability/
Adhesion

Differentiation/
KeptPhenotype

Matrix
Synthesis Material CellType Growth Mineralization Remarks References

BG disks mFLBs + + BG dissolution products

responsible for enhanced
mineralization

[31]

BG-E HMVEC + + + + − ↑ VEGF; promoting

angiogenesis; ionic
concentration critical

[9]

Note: BG, bioactive glass; BG-E, bioactive glass extract (ionic product solution); VEGF, vascular endothelial growth factor; mFLBs, murine fetal long bones;

HMVEC, human micro-vascular endothelial cells.

TABLE 9.13
Cellular Evaluation of Bioactive Glasses

Outcome

Porous
Material

Viability/
Adhesion

Differentiation/
KeptPhenotype

Matrix
Synthesis CellType Growth Mineralization Remarks References

DAB BMSC + + + [10]

BG Primary OB,

human

+ + + Mineralization

without the
addition of
growth factors

[11]

58S Osteoblasts + + + + + [12]

70/30 Osteoblasts + + + + + [36]

58S-E fHOBs, hES + + + + + [36]

70/30-E fHOBs, hES + + + + + [36]

Note: BG, bioactive glass; 58S, 58% SiO 2 -36%CaO-6%P 2 O 5 glass composition; 58S-E, ionic dissolution products extract solution; 70/30, 70% SiO 2 -30%CaO glass

composition; 70/30-E, ionic dissolution products extract solution; BMSC, bone marrow stromal cells; OB, osteblast; DAB, D-Alk-B (borosilicate glass) glass-
based scaffolds; fHOB, fetal human osteoblasts; hES, human embryonic stem cells.