Biomedical Engineering Reference
In-Depth Information
TABLE 8.2
Summary of Studies Investigating Propertie
s of LbL Films in Vivo
FilmTypeandExperimentalModel
MainFindings
Reference
(PLL/PGA) αMSH ilms deposited on tracheal
prostheses
- Fibroblastic colonization of the peripharic site and respiratory epithelium
on the internal side
- More regular layer on PGA ending ilms
- IL-10 production only when MSH is present
Schultz et al. 2005
(CHI/HA) native and X-linked ilms in a rat
mouth model
- Much slower degradation of X-linked ilms
- 60% of the ilm retained on PMMA disks
Etienne et al. 2005
(CHI/HA) native and X-linked in a mouse
peritoneal cavity
- Partial degradation of CL ilms
- Control of degradation by MW and extent of ilm X-linking
Picart et al. 2005b
(PLL/ALG)-PC coated alginate microcapsules
- Adherent cells at the periphery of the capsule
- macI positive cells, no type B and T lymphocytes
Wilson et al. 2007
PAH/DNA or poly(d-lysine)/DNA in rats
- Uniform tissue response
- Induction of ibrous tissue capsules for all the conditions
van den Beucken et al.
2007b
(PLL/PGA)-laminin 5 derived peptide or CL
ilms on porous titanium
- Focal contact formation on CL ilms
- Colonization of the implant by cells of soft tissue
Werner et al. 2009
(PDDA/clay platelet) ilms
In inverted colloidal crystals
- High vascularization around the construct
- Production of CD34+ cells
- Presence of both mature and immature precursor cells
Nichols et al. 2009
Bis-ureio-surfactant and DNA coating in rats
- Increase of bone to implant contact after 1 week
- Simulated body luid DNA based coating was found to increase both early
and late peri-implant bone respone
Schouten et al. 2009
(CHI/HEP) ilm on stainless steel coronary
stents in pigs
- Promotion of reendothelialization on the ilm
- Improved anticoagulation properties
Meng et al. 2009
Source:
Boudou et al.,
Adv. Mater.
, 21, 1-27, 2009. Copyright Wiley-VCH Verlag GmbH & Co. KGaA 2010. With permission.
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