Coating of Material Surfaces with Layer-by- Layer Assembled Polyelectrolyte Films - Biological and Biomedical Coatings: Processing and Characterization - page 362

TABLE 8.1 (Continued)
PEM Coatings on Materials for Different Tissue Engineering Applications

Application Substrate Film Cells MainFindings Reference

Dental
applications

Ti and SiO 2 (PLL/PGA)-

PGA- EMD

- - Immobilization of enamel matrix derivate (EMD) both

on top and within PEM ilms

Halthur et al.
2006

Porous Ti (PLL/PGA) and

laminin
derived
peptide

Epithelial cells - In vitro, the ilms enhance epithelial cell colonization

and proliferation
- Speciic formation of adhesive structures
(hemidesmosomes) in the presence of the peptide

Werner et al.
2009

PMMA disks (CHI/HA) - - Enhanced resistance to enzymatic degradation of

X-linked ilms

Etienne et al.
2005b

Ti (PAH/PSS)

(PLL/HA)

Fibroblasts - Enhanced adhesion and proliferation on (PAH/PSS)

ilms

Brunot et al.
2008

Tracheal
prostheses

Ti (PLL/PGA-

αMSH)

- - In vivo study (see Table 8.2) Schultz et al.

2005

3D porous Ti (PSS/PAH)

(PLL/PGA)

Chondrosarcomas - More stable adhesion (focal contacts) on negatively

charged or uncoated surfaces

Vautier et al.
2003

3D porous Ti (PAH/PSS)

(PLL/PGA)

Endothelial cells - Enhanced spreading and proliferation of endothelial

cells via activation of VEGFR2 receptors and
downstream kinases

Muller et al.
2008

Source: Boudou et al., Adv. Mater. , 21, 1-27, 2009. Copyright Wiley-VCH Verlag GmbH & Co. KGaA 2010. With permission.