Biomedical Engineering Reference
In-Depth Information
8
CoatingofMaterialSurfaceswithLayer-by-Layer
Assembled
PolyelectrolyteFilms
ThomasCrouzier,ThomasBoudou,KefengRen,andCatherinePicart
CONTENTS
Introduction ................................................................................................................................. 334
Processing Parameters Influencing Film Growth and Structure.......................................... 336
Driving Forces for Film Buildup .......................................................................................... 336
Different Deposition Methods: Dip Coating, Spraying, Spin Coating ........................... 336
Growth Mode: Linear versus Exponential ......................................................................... 337
Film Hydration and Swellability: Sensitivity to External Parameters Such as pH
and Ionic Strength .................................................................................................................. 338
Influence of Molecular Weight on Film Buildup ............................................................... 339
Mechanical Properties ........................................................................................................... 340
Protein Adsorption and Cell Adhesion onto PEM Films .....................................................344
Nonfouling Films ...................................................................................................................344
Films Made of Synthetic Polyelectrolytes as Cell Adhesive Substrates .........................344
Film as Mimics of Extracellular Matrix for Specific Cell Cultures .................................. 345
ECM Protein and Peptide Coatings on PEM Films........................................................... 346
Antibacterial Coatings ........................................................................................................... 348
Film Biodegradability ............................................................................................................ 349
Delivery of Bioactive Molecules to Cells via PEM Films ...................................................... 351
Small Molecules or Drugs ..................................................................................................... 351
Surface Mediated Transfection ............................................................................................. 353
Bioactive Proteins and Growth Factors............................................................................... 354
Cell and Stem Cell Differentiation ....................................................................................... 355
Cell Encapsulation ................................................................................................................. 357
Toward Biomedical Applications.............................................................................................. 358
PEM-Coated Implantable Biomaterials............................................................................... 358
In Vivo Studies on PEM-Coated Materials ......................................................................... 364
Acknowledgments ...................................................................................................................... 364
List of Abbreviations................................................................................................................... 364
References..................................................................................................................................... 365
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