Bioceramic Coating on Titanium by Physical and Chemical Vapor Deposition - Biological and Biomedical Coatings: Processing and Characterization - page 324

50

*

: Control
: ACP

40

30

20

10

0

2-4 weeks 8-12 weeks

FIGURE 7.34
Percentage of bone-implant contact of ACP-coated and noncoated (control) CP Ti cylinders (* p < 0.05).

Yoshinari et al. (47) immobilized bisphosphonates on calcium phosphate coatings on Ti
substrates prepared by IBD and showed that the initial adherence of bacteria (87) was sup-
pressed and the BIC values in the mandibles of beagle dogs were increased. (85) Coatings by
vapor deposition can be applied to surface modification of metallic biomaterials in combi-
nation with the immobilization of biomolecules.

(a)

Resin

Bone

Ti-6Al-4V

5 µm

(b)

Resin

Bone

Coating

Ti-6Al-4V 5 µm

FIGURE 7.35
SEM images of cross section of (a) ACP- and (b) OAp-coated Ti implants after implantation in femurs of Japanese
white rabbits for 4 weeks.