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between 1.87 and 12.67 μM for SMMC-7721 cells and 2.20 and 6.79 μM for A549
cells, respectively. Structure-activity relationships indicating that acylthioureas in
which the furan group was fused with the Δ
8
-dihydroabietyl group, and acylthioureas
in which the trihydroxymethyl group was fused with the Δ
8
-dihydroabietyl group
or the dehydroabietyl group, showed enhanced activities against SMMC-7721 and
A549 cells.
Table 6.2 Inhibition ratios of compounds (19-22) against SMMC-7721 cells at
different concentration
R
Compounds
IC
50
R
1
R
2
19
H
H
8.8
20
H
p
-FPh
14.2
21
H
3,5-F
2
Ph
12.8
NR
1
R
2
=
N
22
10.2
Data adapted from reference [18]
Scheme 6.6
Structure of unsymmetrically disubstituted acylthioureas (
23
-
25
)
